PiCSOAMI Therapy aims to improve myocardial perfusion and cardiac function in patients with myocardial infarction by redistributing blood flow into the damaged area during PCI.

Pre-clinical and clinical studies demonstrated that PiCSO, in addition to standard PCI, may significantly reduce the infarct size after acute myocardial infarction. Infarct size has shown to be strongly predictive of subsequent all-cause mortality and rehospitalization for heart failure after primary PCI.

PiCSOAMI Therapy is applied immediately following flow restoration and during coronary artery stenting in patients presenting with acute myocardial infarction. The therapy is automatically adapted to the patient’s individual anatomy and hemodynamics and extends average cath lab time by only 20-30 minutes.

The PiCSOAMI Impulse System consists of a balloon tipped catheter and a driving console. The PiCSOAMI Impulse Catheter is inserted in a standard manner via the femoral vein and placed in the coronary sinus using a steerable guide sheath (Figure 2). Intermittent coronary sinus occlusion is controlled by the PiCSOAMI Impulse Console using the unique, proprietary ‘Wien Algorithm’ which continuously monitors coronary sinus pressure dynamics and automatically sets the time of occlusion and release phases based on venous pressure.

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